MovDisordV3, Main, Exploration, bibRecord, 002B37

The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson's disease: A double blind placebo‐controlled pilot study

Identifieur interne : 002B37 ( Main/Exploration ); précédent : 002B36; suivant : 002B38

The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson's disease: A double blind placebo‐controlled pilot study

Auteurs : Tanya Gurevich [Israël] ; Chava Peretz [Israël] ; Orna Moore [Israël] ; Nina Weizmann [Israël] ; Nir Giladi [Israël]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-04-30.

RBID : ISTEX:6F3A511E37DFD18E49BDBCE13207147F990A0410

Descripteurs français

Pascal (Inist)
- Bontoxilysin, Congélation, Etude double insu, Muscle strié, Parkinson maladie, Placebo, Système nerveux pathologie.
Wicri :
- topic : Congélation.

English descriptors

KwdEn :
- Bontoxilysin, Botulinum Toxins, Type A (administration & dosage), Botulinum Toxins, Type A (therapeutic use), Double blind study, Double-Blind Method, Female, Follow-Up Studies, Freezing, Humans, Injections, Intramuscular, Leg, Male, Movement Disorders (drug therapy), Movement Disorders (etiology), Muscle, Skeletal, Nervous system diseases, Neuromuscular Agents (administration & dosage), Neuromuscular Agents (therapeutic use), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Pilot Projects, Placebo, Placebos, Striated muscle, Treatment Outcome, botulinum toxin, falls, freezing of gait.
MESH :
- chemical , administration & dosage : Botulinum Toxins, Type A, Neuromuscular Agents.
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- drug therapy : Movement Disorders, Parkinson Disease.
- etiology : Movement Disorders.
- physiopathology : Parkinson Disease.
- Double-Blind Method, Female, Follow-Up Studies, Humans, Injections, Intramuscular, Leg, Male, Muscle, Skeletal, Pilot Projects, Placebos, Treatment Outcome.

Abstract

Objective: To assess the effect on freezing of gait (FOG) of botulinum toxin type A (BTX‐A) injections in advanced Parkinson's disease (PD) patients. Method: BTX‐A 150 IU or normal saline was injected into each leg's calf muscles by a blinded investigator. FOG severity was assessed at set intervals (6‐month follow‐up). Results: Eleven age‐ and disease severity‐matched PD patients with disabling FOG participated. Six patients received BTX‐A and 5 received saline. No improvement was observed in either group over time. Leg weakness and falls lead to early termination. Conclusion: BTX‐A injections to the legs did not improve FOG and might increase fall risk. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/6F3A511E37DFD18E49BDBCE13207147F990A0410/fulltext/pdf

DOI: 10.1002/mds.21396

Affiliations:

Israël

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<term>Double blind study</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Freezing</term>
<term>Humans</term>
<term>Injections, Intramuscular</term>
<term>Leg</term>
<term>Male</term>
<term>Movement Disorders (drug therapy)</term>
<term>Movement Disorders (etiology)</term>
<term>Muscle, Skeletal</term>
<term>Nervous system diseases</term>
<term>Neuromuscular Agents (administration & dosage)</term>
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<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Pilot Projects</term>
<term>Placebo</term>
<term>Placebos</term>
<term>Striated muscle</term>
<term>Treatment Outcome</term>
<term>botulinum toxin</term>
<term>falls</term>
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<term>Follow-Up Studies</term>
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<term>Injections, Intramuscular</term>
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<front><div type="abstract" xml:lang="en">Objective: To assess the effect on freezing of gait (FOG) of botulinum toxin type A (BTX‐A) injections in advanced Parkinson's disease (PD) patients. Method: BTX‐A 150 IU or normal saline was injected into each leg's calf muscles by a blinded investigator. FOG severity was assessed at set intervals (6‐month follow‐up). Results: Eleven age‐ and disease severity‐matched PD patients with disabling FOG participated. Six patients received BTX‐A and 5 received saline. No improvement was observed in either group over time. Leg weakness and falls lead to early termination. Conclusion: BTX‐A injections to the legs did not improve FOG and might increase fall risk. © 2007 Movement Disorder Society</div>
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Movement Disorders (revue)

The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson's disease: A double blind placebo‐controlled pilot study

The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson's disease: A double blind placebo‐controlled pilot study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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